Design and Evaluation of Ciprofloxacin Hydrochloride Ocular Inserts
نویسندگان
چکیده
Ocular Conjunctivitis is one of the main causes of red eye syndrome. The present work focuses on the treatment of ocular conjunctivitis by using combined mechanisms: 1.Formulation of ocular inserts to provide prolonged and sustained release system of the drug. 2.Use of therapeutic agent, as ciprofloxacin hydrochloride in combination with the polymers used. The selected polymers were methylcellulose (MC), hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose (HPC), and Eudragit RS100 (ERS 100). The developed ocular inserts were evaluated for physic-chemical, mechanical, drug release, drug permeability, and In-vivo characteristics. The ocular inserts showed desired delivery of the drug to the ocular tissue of the rabbit’s eye. In-vivo studies showed that ciprofloxacin hydrochloride had a significant effect on reduction of induced ocular conjunctivitis.
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